Add cooking oil, garlic powder, onion powder, paprika, oregano, salt and pepper to a large bowl and mix together.
Add the chicken thighs and mix with the sauce so that chicken is evenly coated.
Lightly coat the inside of the air fryer tray or basket with olive oil or cooking spray. Preheat the air fryer to 400°F for 2 minutes.
Place chicken thighs in a single layer in the air fryer. Cook for 12 minutes with the skin side facing down.
Use a pair of tongs to flip the chicken over. Cook an additional 12-17 minutes or until chicken reaches 165°F as an internal temperature when poked with a meat thermometer. Remove from air fryer and serve.