Bubble Up Pizza Biscuit Casserole

Name: Bubble-Up Pizza Biscuit Casserole
Prep time: 10 min
Cook time: 30 min
Total time: 40 min
Ingredients: 2 cans refrigerated biscuit dough; 1 cup pizza sauce; 1 ½ cups shredded mozzarella; ½ cup mini pepperoni; 2 Tbsp grated parmesan (optional); ½ tsp dried oregano (optional); ½ tsp Italian seasoning

If your family loves an easy pizza recipe that practically makes itself, this pizza biscuit casserole will be a big win in your house. It is gooey, cheesy, and one of the best lazy dinners you can pull together with pantry staples. Kids love the bite-size biscuit pieces and you will love how fast it comes together on busy weeknights.👇👇

Baked pizza biscuit casserole in a 9x13 metal pan with golden cheese and pepperoni on top.

Quick Note From Andi

Andi Anne holding a freshly baked pizza biscuit casserole in her kitchen, showing the golden cheese and pepperoni on top.

Whenever I need a dinner that gets instant cheers from my daughter, this is the one I pull from my back pocket. It tastes like a cross between cheesy pull-apart biscuits and a classic pepperoni pizza, and everyone seems to magically wander into the kitchen as soon as it starts smelling good. It is simple, fun, and always disappears fast, which is exactly what I want from a healthy homemade recipe on a weeknight.

Need another easy hack? Try my garlic toast pizzas!

Why I Love This Recipe

If you need a quick dinner idea that checks the boxes for easy, budget friendly, and family friendly, this one is it.

One bowl prep - Toss everything together, pour it into the pan, and bake.
Kid approved - Bite-size biscuits, gooey cheese, and mini pepperoni make it an instant favorite.
Pantry staples - Uses ingredients you can keep on hand for emergency meals and quick dinner ideas.
Customizable - Swap proteins, add veggies, or switch sauces for your version of a bubble up pizza casserole.
Fast cook time - Ready to eat in about 40 minutes, which makes it perfect for easy weeknight recipes.
Great for meal prep - Leftovers reheat beautifully for next-day lunches.

Ingredients For Recipe 👇👇

2 cans refrigerated biscuit dough - like Pillsbury Grands or your favorite brand
1 cup pizza sauce
1 ½ cups shredded mozzarella
½ cup mini pepperoni
2 Tbsp grated parmesan - optional
½ tsp dried oregano - optional
½ tsp Italian seasoning

Step-By-Step Instructions 👇👇

STEP 1: Preheat the oven

Preheat your oven to 375°F and lightly grease a 9×13 metal baking dish with a little extra virgin olive oil. This keeps the biscuits from sticking and helps give the edges a light golden finish.

Canned fridge biscuits are chopped into chunks on a cutting board with a knife.

STEP 2: Cut the biscuit dough

Use a sharp knife or kitchen scissors to cut 2 cans of refrigerated biscuit dough into quarters. Keep the pieces roughly the same size so they bake evenly.

TIP: If your oven runs cooler or you are worried about a doughy center, cut some of the biscuits into smaller pieces.

STEP 3: Mix everything in one bowl

In a large bowl, toss the biscuit pieces with 1 cup pizza sauce and ½ cup shredded mozzarella. Use a wooden spoon to gently combine until each piece is coated without clumping. The mixture should look saucy and cheesy but not soggy - every biscuit should be coated, not swimming.

Chopped biscuit pieces with pizza sauce, topped with mozzarella cheese and pepperoni.

STEP 4: Spread into the baking dish

Pour the mixture into your greased 9×13 baking dish and spread it into an even layer using a silicone spatula. Make sure no big clumps of biscuits are hiding in the center or corners, or they may not bake through as quickly as the rest of the bubble up pizza casserole.

STEP 5: Add seasoning and parmesan

Sprinkle ½ tsp Italian seasoning over the top. Add 2 Tbsp parmesan and ½ tsp dried oregano if you love extra pizza flavor. Sprinkle 1 cup mozzarella cheese and add mini pepperoni slices. These create a lightly crisp, savory top that browns beautifully in the oven.

You can add any other desired toppings at this time as well.

STEP 6: Bake until golden and bubbly

Bake for 25 to 30 minutes until the biscuits are golden and the cheese is bubbling around the edges. Look for a slightly puffed top and melted cheese with crisp edges. If the center still looks doughy when you check with a toothpick, bake another 3 to 5 minutes and check again.

A pan filled with pizza biscuit casserole is on the counter with a slice removed.

STEP 7: Cool and serve

Let the pizza biscuit casserole cool for about 5 minutes so it can set before slicing. Serve warm with extra pizza sauce on the side, ranch dressing, or a simple green salad for an easy weeknight dinner.

Golden baked pizza biscuit casserole with bubbly cheese and pepperoni slices just out of the oven.

Recipe Tips

Cut biscuits evenly - Same size pieces bake at the same speed, so nothing is raw in the middle.
Coat every piece - Toss gently so each biscuit gets sauce and cheese, which helps it "bubble up" evenly.
Use a metal baking dish - Metal pans brown better and help the center cook through faster than glass or ceramic.
Check at 25 minutes - You want golden tops, flaky biscuit layers, and bubbly cheese.
Let it cool - It needs a few minutes to set, so slices hold together when you scoop them out.
Avoid overmixing - Too much stirring can make the biscuits dense instead of fluffy.
Add extra flavor - A pinch of red pepper flakes or extra parmesan on top gives that pizzeria flavor.
Serve with dipping sauces - Marinara, ranch, or garlic butter are always a hit.
Shred your own cheese - Freshly shredded mozzarella melts smoother and stretches better.
Line pan with parchment - Makes cleanup easy on nights when you are running on fumes.

Variations and Substitutions

Use cooked sausage - Swap mini pepperoni for 1 cup cooked crumbled Italian sausage.
Veggie boost - Add diced bell peppers, sliced mushrooms, or black olives right into the mix.
Different cheese - Try provolone, cheddar, Monterey Jack, or your favorite cheese blend.
Swap the sauce - Use marinara or tomato sauce if you are out of pizza sauce.
Add garlic - Mix in 1 to 2 minced garlic cloves or ½ tsp garlic powder for extra flavor.
Make it spicy - Add red pepper flakes or diced jalapeños.
Add cooked chicken - Stir in 1 cup shredded cooked chicken for extra protein and a heartier casserole.

What To Serve With

Simple green salad with Italian salad dressing: Bright, crunchy greens lighten the rich, cheesy bake.
Lemon garlic broccoli: Kids actually eat it when it's next to something pizza flavored.
Sauteed green beans: Quick stovetop veggie with tons of flavor.
Fresh fruit bowl: Strawberries, pineapple, or grapes for a sweet balance.

How To Store Leftovers

Fridge: Keep leftovers in an airtight container for up to 3 days.
Reheat: Warm in a 350°F oven for crisp edges, or microwave for a softer texture.
Freezing: Not ideal after baking because the biscuits soften, but you can freeze the unbaked biscuit pieces tossed with sauce and cheese for up to 2 months, then bake from thawed.

Dinner Rhythm Tip

If you're following my Dinner Rhythm Blueprint, this recipe works perfectly as a grace night meal.

Option 1: Serve it fresh with a simple side dish like roasted veggies or a salad kit for a balanced weeknight dinner.
Option 2: Use leftovers for quick lunches - reheat and serve with a side of fruit, soup, or raw veggies with dip.
Option 3: You can also use a can of biscuit dough in tons of other ways - think mini breakfast sandwiches, quick garlic knots, pull-apart bread, or little lunchbox pizzas for easy weekday meals.

More Easy Pizza Hacks

Twisted Pizza Breadsticks (with Pillsbury pizza crust)
Chili Garlic Pizza Bread
Homemade Pizza Pockets (pillsbury pizza crust)
Bacon Sausage Breakfast Pizza
Pizza Pasta Bake
Pizza Sloppy Joes

Biscuit pieces mixed with pizza sauce, pepperoni slices, and cheese in a casserole dish, with a slice removed.

FAQs

Can I use homemade biscuit dough?

Yes, homemade biscuit dough will work as long as you cut it into small, even pieces. Keep an eye on the bake time and check the center with a toothpick to make sure it is cooked through.

Can I make pizza biscuit bake ahead of time?

You can assemble the casserole, cover it, and refrigerate it for up to 24 hours before baking. When you are ready to bake, let the dish sit at room temperature for about 15 minutes, then bake until the biscuits are puffed and the cheese is melted.

Can I use marinara instead of pizza sauce?

Yes, marinara or even plain tomato sauce both work in this recipe. If you use plain tomato sauce, add a little extra Italian seasoning and garlic to get that classic pizza flavor.

Do I need to pre-bake the biscuits?

You do not need to pre-bake the biscuits for this recipe. If your oven bakes unevenly or you are using a glass dish, you can pre-bake the biscuit pieces for 5 to 8 minutes before adding the sauce and cheese to help the center cook through.

Can I make it without pepperoni?

Absolutely. Leave the pepperoni out for a simple cheese pizza casserole, or swap it for your favorite toppings like cooked sausage, mushrooms, or peppers.

Why is my center still doughy?

If the center is still doughy, it usually means the biscuits were too large or the pan needs a little more time in the oven. Cut the biscuits smaller next time, use a metal baking dish, and add an extra 5 minutes of bake time, checking the center with a toothpick.